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dc.creatorWileidy Andrea Gómez Calderón-
dc.creatorMaría Mercedes Ball Vargas-
dc.creatorWilmar Alirio Botello Suárez-
dc.creatorLuis Andrés Yarzábal Rodríguez-
dc.descriptionBacteria colonizing heavily polluted tailing ponds in Southern Venezuela exhibit multiple resistances against mercurial compounds and antibiotics. The corresponding genetic determinants, mainly acquired through horizontal gene transfer, might also be transferred to pathogenic bacteria, an issue which represents an important risk to public health. In this work we show that indigenous, mercury-resistant bacterial strains isolated from a model tailing pond, located in El Callao (Bolivar State, Venezuela) and exhibiting a high concentration of soluble Hg, were able to transfer in vitro both heavy metal- and antibiotic resistance markers to potential human- and animal- pathogens (i.e. Escherichia coli and Pseudomonas aeruginosa). The frequencies of transfer ranged between 1.2x10-6 and 5.5x10-7 transconjugants per recipient. Transconjugants were also detected in the field, in model biofilms previously grown in natural sponges (Luffa cylindrica) and submersed in the ponds, at frequencies ranging from 1x10-4 to 5x10-3 transconjugants per recipient. These results are of particular relevance from the public health viewpoint, especially in light of the potential risk of horizontal flow of antibiotic resistance genes between indigenous bacteria and potential human pathogens.-
dc.publisherSociedad Venezolana de Microbiología-
dc.rightsRevista de la Sociedad Venezolana de Microbiología-
dc.sourceRevista de la Sociedad Venezolana de Microbiología (Venezuela) Num.2 Vol.33-
dc.subjectmercury resistance-
dc.subjectantibiotic resistance-
dc.subjecthorizontal gene transfer-
dc.titleHorizontal transfer of heavy metal and antibiotic-resistance markers between indigenous bacteria, colonizing mercury contaminated tailing ponds in southern Venezuela, and human pathogens-
dc.typeArtículo científico-
Aparece en las Colecciones:Revista de la Sociedad Venezolana de Microbiología

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