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|Título:||ATM polymorphisms IVS24-9delT, IVS38-8TC, and 5557GA in Mexican women with familial and/or early-onset breast cancer|
Ataxia telangiectasia mutated (ATM)
single nucleotide polymorphisms (SNP)
|Editorial:||Instituto Nacional de Salud Pública|
|Descripción:||Objective. To assess whether in Mexican population the frequencies of ATM polymorphisms IVS24-9delT, IVS38-8TC, and 5557GA in breast cancer (BC) cases and healthy controls were different from those found in other countries. Materials and methods. Frequencies of polymorphisms conferring BC risk IVS24-9delT, IVS38-8TC, and 5557GA were analyzed by PCR-RFLP in 94 patients with familial and/or early onset BC, and 97 healthy controls randomly selected. Allele frequencies analysis was done using χ2 and Hardy-Weinberg test. Results. Frequencies of heterozygous were: for 5557GA, 13% cases, 0%controls (p=0.0009); for IVS24-9delT, 21% cases, 8% controls (p=0.0122); for IVS38-8TC, only one case. 5557GA and IVS24-9delT were more frequent in cases than in controls. The allelic frequencies found in 5557GA are similar to those described by González-Hormazábal in Chile. Conclusion. The similarity of results in this polymorphism between Chilean and Mexican populations may be due to both being crossbred with an Amerindian-Spanish component, while differences may be due to fact that Chilean population has a greater European component than Mexicans.|
|Aparece en las Colecciones:||Anales de la Facultad de Medicina|
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